Acupuncture improves receptivity of endometrial lining in IVF Frozen Embryo Transfer

Frozen embryo transfer acupuncture

IVF Frozen Embryo Transfer (FET) patients benefit from Acupuncture. This helps us understand how Acupuncture benefits fertility.

Electro stimulation on acupuncture points leading to the IVF transfer improves the quality/receptivity of the uterine lining. A study published in the latest issue of peer-reviewed British Medical Journal (Acupuncture in Medicine) found the rates of embryo implantation, clinical pregnancy and live birth rates were higher in patients who received acupuncture leading to the transfer. They also found significant measurable changes in the endometrium (uterine lining):

  • Acupuncture improved the chances of triple-line pattern endometrial lining. It has been shown in studies that triple-line pattern is associated with good IVF outcome.
  • Endometrial perfusion (blood supply to the uterine lining) is an important factor in the process of implantation. The study found greater endometrial and subendometrial vascularisation following a series of acupuncture treatments leading to embryo transfer.
  • Acupuncture improved HOXA10 expression. Higher HOXA10 is associated with greater endometrial receptivity and good pregnancy outcomes. HOXA10 expression is lower in the uteri of women with hydrosalpinx, PCOS, and endometriosis.

How much acupuncture should you have to see those enhancements to your fertility? Women in this study had six acupuncture sessions per cycle for three menstrual cycles.

See the abstract of the study below. Read more

Acupuncture and Chinese herbal medicine in treatment of Endometriosis

This study demonstrates that acupuncture has a synergystic effect with Chinese Herbal medicine in treatment of Endometriosis. Furthermore the effect of acupuncture and herbal medicine was found to be superior to a pharmaceutical medicine Danazol. The abstract of the study is below.
Acupuncture Chinese medicine Endometriosis

Acupuncture enhances the effects of Chinese herbal Medicine in treatment of Endometriosis

J. Shi, Z. B. Z. Ge*
, Y. Jin,Y. D. Li and J. Zhou** The 1st Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China
*Sir Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, Zhejiang, China
**College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang, 310012, China. Corresponding Author Email: juezhou2006@yahoo.com.cn

ABSTRACT

The present study was aimed to investigate whether acupuncture could significantly enhance the efficacy of Chinese herbal medicine (CHM) in treating endometriosis model rats. A total of 40 female Sprague-Dawley (SD) rats with body weight of 200 ±20 g were included. Operational transplantation was used with animal models. The rats were randomly divided into 5 groups: sham-operation control group (Group A), model group (Group B), CHM combined with acupuncture group (Group C), CHM group (Group D), Danazol group (Group E) with 8 rats in each group. During the treatment, two rats in Group B and one rat in Group E passed away. When the treatment ended, all the left rats were sacrificed. The samples of peritoneal fluids, serum and the ectopic endometrium were taken. The serum levels of cancer antigen 125 (CA-125) and interleukin 18(IL-18) in the peritoneal fluids were detected using enzyme-linked immune-sorbent assay. The cyclooxygenase-2 (COX-2) mRNA expression levels in the ectopic endometrium were measured by Real-time PCR. The results showed that in the rats from Groups A, C, D and E, the serum CA-125 levels, COX-2 mRNA expression in the ectopic endometrium and the IL-18 levels in the peritoneal fluids were significantly lower than those of Group B (P<0.05). The serum CA-125 levels and COX-2 mRNA expression in the ectopic endometrium of the rats in Group C were significantly lower than those of Group D (P<0.05), while there was no significant difference between Group C and E (P>0.05). The levels of IL-18 in the peritoneal fluids of the rats in Group C were markedly lower than those of Group D and E (P<0.05). It is then concluded that acupuncture treatment can improve the effects of CHM in treating endometriosis model rats. Key words: Chinese herbal medicine acupuncture; endometriosis Reference: The Journal of Animal & Plant Sciences, 23(1): 2013, Page: 298-303 ISSN: 1018-7081

You can find a copy of the study here.

Chinese herbal medicine vs gestrinone for endometriosis

Cochrane: Endometriosis and Chinese medicineChinese herbal medicine for endometriosis

Flower A, Liu JP, Chen S, Lewith G, Little P
Chinese herbs for endometriosis

Endometriosis is a common gynaecological condition causing menstrual and pelvic pain. Treatment involves surgery and hormonal drugs, with potentially unpleasant side effects and high rates of reoccurrence of endometriosis. This review suggests that Chinese herbal medicine (CHM) may be useful in relieving endometriosis-related pain with fewer side effects than experienced with conventional treatment. However, the two trials included in this review are of poor methodological quality so these findings must be interpreted cautiously. Better quality randomised controlled trials are needed to investigate a possible role for CHM in the treatment of endometriosis.

This is a Cochrane review abstract and plain language summary, prepared and maintained by The Cochrane Collaboration, currently published in The Cochrane Database of Systematic Reviews 2009 Issue 3, Copyright © 2009 The Cochrane Collaboration. Published by John Wiley and Sons, Ltd.. The full text of the review is available in The Cochrane Library (ISSN 1464-780X).
This record should be cited as: Flower A, Liu JP, Chen S, Lewith G, Little P. Chinese herbal medicine for endometriosis. Cochrane Database of Systematic Reviews 2009, Issue 3. Art. No.: CD006568. DOI: 10.1002/14651858.CD006568.pub2

This version first published online: July 08. 2009
Abstract
Background

Endometriosis is characterized by the presence of tissue that is morphologically and biologically similar to normal endometrium in locations outside the uterus. Surgical and hormonal treatment of endometriosis have unpleasant side effects and high rates of relapse. In China, treatment of endometriosis using Chinese herbal medicine (CHM) is routine and considerable research into the role of CHM in alleviating pain, promoting fertility, and preventing relapse has taken place.
Objectives

To review the effectiveness and safety of CHM in alleviating endometriosis-related pain and infertility.
Search strategy

We searched the Menstrual Disorders and Subfertility Group Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library) and the following English language electronic databases (from their inception to the present): MEDLINE, EMBASE, AMED, CINAHL, NLH on the 30/04/09.

We also searched Chinese language electronic databases: Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Chinese Sci & Tech Journals (VIP), Traditional Chinese Medical Literature Analysis and Retrieval System (TCMLARS), and Chinese Medical Current Contents (CMCC).
Selection criteria

Randomised controlled trials (RCTs) involving CHM versus placebo, biomedical treatment, another CHM intervention, or CHM plus biomedical treatment versus biomedical treatment were selected. Only trials with confirmed randomisation procedures and laparoscopic diagnosis of endometriosis were included.
Data collection and analysis

Risk of bias assessment, and data extraction and analysis were performed independently by three review authors. Data were combined for meta-analysis using relative risk (RR) for dichotomous data. A fixed-effect statistical model was used, where appropriate. Data not suitable for meta-analysis are presented as descriptive data.
Main results

Two Chinese RCTs involving 158 women were included in this review. Both these trials described adequate methodology. Neither trial compared CHM with placebo treatment.

There was no evidence of a significant difference in rates of symptomatic relief between CHM and gestrinone administered subsequent to laparoscopic surgery (95.65% versus 93.87%; risk ratio (RR) 1.02, 95% confidence interval (CI) 0.93 to 1.12, one RCT). The intention-to-treat analysis also showed no significant difference between the groups (RR 1.04, 95% CI 0.91 to 1.18). There was no significant difference between the CHM and gestrinone groups with regard to the total pregnancy rate (69.6% versus 59.1%; RR 1.18, 95% CI 0.87 to 1.59, one RCT).

CHM administered orally and then in conjunction with a herbal enema resulted in a greater proportion of women obtaining symptomatic relief than with danazol (RR 5.06, 95% CI 1.28 to 20.05; RR 5.63, 95% CI 1.47 to 21.54, respectively).

Overall, 100% of women in all the groups showed some improvement in their symptoms.

Oral plus enema administration of CHM showed a greater reduction in average dysmenorrhoea pain scores than did danazol (mean difference (MD) -2.90, 95% CI -4.55 to -1.25; P < 0.01). Combined oral and enema administration of CHM showed a greater improvement, measured as the disappearance or shrinkage of adnexal masses, than with danazol (RR 1.70, 95% CI 1.04 to 2.78). For lumbosacral pain, rectal discomfort, or vaginal nodules tenderness, there was no significant difference either between CHM and danazol. Authors' conclusions Post-surgical administration of CHM may have comparable benefits to gestrinone but with fewer side effects. Oral CHM may have a better overall treatment effect than danazol; it may be more effective in relieving dysmenorrhea and shrinking adnexal masses when used in conjunction with a CHM enema. However, more rigorous research is required to accurately assess the potential role of CHM in treating endometriosis.