Picture this: a lovely couple nervously sits in front of me during their first fertility acupuncture consultation. They want to know how acupuncture can help with male factor infertility.
Due to the male factor infertility diagnosis, the couple had already gone through three cycles of IVF with ICSI, recommended by a reproductive endocrinologist. Sadly, none of these cycles resulted in viable embryos. The gentleman’s eyes fill with tears as he shares his story.
He says, “I’m super healthy! I don’t smoke, drink or eat junk food, I work out regularly. Still… Nothing. We’re willing to try anything at this point.”.
https://infertility-acupuncture.info/wp-content/uploads/2021/03/semen-quality-acupuncture.jpg4741200Roberta Mekhttps://infertility-acupuncture.info/wp-content/uploads/2015/03/Infertility-acupuncture-logo-300x152.pngRoberta Mek2021-03-04 17:11:452023-02-18 07:39:26Acupuncture to support sperm quality – where do you put the needles?
Effects and mechanisms of acupuncture and moxibustion on reproductive endocrine function in male rats with partial androgen deficiency.
Ren Y1, Yang X1, Zhang Y2, Wang Y1, Li X1.
Partial androgen deficiency of the aging male (PADAM) is characterised by a deficiency in serum androgen levels. Both electroacupuncture (EA) and mild moxibustion (MM) can raise serum testosterone levels in PADAM. We investigated the mechanisms underlying the use of EA and MM in a rodent model of PADAM. Read more
https://infertility-acupuncture.info/wp-content/uploads/2015/10/androgen-acupuncture.jpg7681157Vitalis Skiauterishttps://infertility-acupuncture.info/wp-content/uploads/2015/03/Infertility-acupuncture-logo-300x152.pngVitalis Skiauteris2015-10-27 12:52:332018-12-11 13:43:47Acupuncture and moxibustion help androgen deficiency
Impact of stress on female infertility and pregnancy has been well documented. Below study, published in the journal of Fertility and Sterility, shows male reproductive health is similarly affected by it. The researchers are confident the correlation between stress and sperm parameters is clear.
In a world that is increasingly reliant on scientific innovation, there remains a treasure trove of wisdom in ancient practices that continues to surprise and delight us. It’s not often that these two realms join forces, but when they do, the results can be groundbreaking. Today, we delve into a remarkable study that combined ancient Chinese medicine with modern knowledge of vitamin E to tackle a sensitive issue – male fertility.
The Challenge: Idiopathic Oligoasthenospermia
Male infertility can be a complex and often stigmatised topic, and a common cause is a condition called idiopathic oligoasthenospermia. In plain language, this essentially means that sperm quality is low, and the exact cause remains a mystery. But hope is on the horizon, thanks to the innovative work of researchers Song, He, Jiang, Peng, Wu, and Cao.
What is semen liquefaction? Immediately after ejaculation semen coagulates and then liquefies again within 15 to 20 minutes. Unfortunately, for about 11.8 per cent of men, diagnosed with infertility, semen does not liquefy.
One of the main causes, why sperm doesn’t liquefy, is inflammation. To be precise, the inflammation of the prostate and seminal vesicles. As a result, because of the impaired function, these glands may secrete less of the sperm fluid. Therefore, lead to lower semen quality and trouble with liquefaction.
This study shows that Chinese herbs can reduce semen liquefaction time. As a result, sperm motility and concentration improved as well.
Shengjing Tablets used in this study include nine TCM/herbal ingredients. The key to success here is not prescribing just any herbs. The most important is the combination and dose of each ingredient that makes the formula successful.
Shengjing tablets for semen non-liquefaction: a clinical study of 100 cases.
[Article in Chinese]
Yang XF, Guo LH, An LH, Pan ZH, Sun L, Ma K
To investigate the efficacy and action mechanism of Shengjing Tablets in the treatment liquefaction.
We randomly assigned 150 patients with semen non-liquefaction to receive Shengjing Tablets group, n = 100) and vitamin E capsules (control group, n = 50) for 2 courses of 45 days each, followed by observation liquefaction time and other semen parameters.
After the first course, 68 of the patients in the treatment group 20 responded and 12 failed to respond; and after the second course, 84 were cured, 9 responded and 7 failed to respond, the effective rate of 93.0%. In comparison, only 8 of the controls were cured, 8 responded and 34 failed to respond after medication. There were statistically significant differences between the two groups (P < 0.01). Meanwhile, the treatment showed obvious improvement in sperm motility and concentration.
Shengjing Tablets may shorten the time liquefaction and can be used as a safe and effective therapy for semen non-liquefaction.
This study published in journal of Spermatogenesis contributes to understanding of how acupuncture improves sperm parameters. The researchers found that acupuncture improved Sertoli cell functions. This has enhanced germ cell proliferation. The result is improved motile sperm count. The study design could not evaluate other sperm parameters.
Spermatogenesis. 2012 Jan 1;2(1):53-62.
Electroacupuncture enhances spermatogenesis in rats after scrotal heat treatment.
Gao J, Zuo Y, So KH, Yeung WS, Ng EH, Lee KF.
Spermatogenesis is regulated by a cascade of steroid regulated genes in the testis. Recent studies suggested that acupuncture may improve fertility in men with abnormal semen parameters. Yet, the underlying mechanisms in which acupuncture enhances spermatogenesis remain largely unknown. Here we used a scrotal heat-treated rat model to study the effect of electroacupuncture (EA) on recovery of spermatogenesis. In this model, spermatogenesis was disrupted by 30 min scrotal heat treatment at 43°C. Ten sessions of EA were given at Baihui (GV20), Guanyuan (CV4), Zusanli (ST36) and Sanyinjiao (SP6) from day 9 to day 36 post-treatment. Sperm motility and production, morphology of the germinal epithelium by Johnsen’s scoring, germ cell apoptosis by TUNEL staining, proliferation by proliferating cell nuclear antigen (PCNA) staining, as well as serum testosterone and inhibin B levels by immunoassays were evaluated on day 0, 1, 9, 25, 37, 46, 56 and 79. When compared with the heat-treated (H) group, the heat-treated plus EA (H(+)EA) group showed a significant increase (p < 0.05) in PCNA-positive cells and inhibin B levels on days 37 and 46, and a higher Johnsen's score till day 56. On day 79, motile spermatozoa could be found in the vas deferens of H(+)EA group only. Consistently, there was a trend of improved motility and increased number of motile epididymal spermatozoa in the H(+)EA group than the H group; while apoptosis of germ cells and serum testosterone levels were similar between the two groups. Taken together, EA enhanced germ cell proliferation through improvement of Sertoli cell functions. This may facilitate the recovery of spermatogenesis and may restore normal semen parameters in subfertile patients.
To observe the clinical efficacy of acupuncture-moxibustion therapy for infertility due to sperm abnormality (SAI).
We treated a series of 35 cases of SAI with electroacupuncture combined with herb cake-partitioned moxibustion, observing the variation before and after treatment in symptom integral, sperm status, sex hormone and prostate function.
After treatment, the patients were remarkably improved in symptom integral, sperm status, sex hormone and prostate function as compared with those prior to treatment.
Acupuncture is an effective therapy for SAI.
Key Words Acupuncture-moxibustion Therapy – Infertility, Male – Spermatozoa – Azoospermia – Oligospermia
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Fertil Steril. 2008 Nov;90(5):1732-8. Epub 2008 Feb 20.
Point- and frequency-specific response of the testicular artery to abdominal electroacupuncture in humans.
Cakmak YO, Akpinar IN, Ekinci G, Bekiroglu N.
Department of Anatomy, School of Medicine, University of Marmara, Istanbul, Turkey. firstname.lastname@example.org
OBJECTIVE: To clarify the role of the abdominal acupuncture points and the frequency of short-term electroacupuncture (EA) stimulation on testicular blood flow (TBF) in humans.
DESIGN: A prospective, randomized study.
SETTING: University hospital, Department of Radiology, ultrasound unit.
PATIENT(S): Eighty healthy male volunteers were randomly allocated to three groups in stage one and to a single group in stage two. In the first stage of the study, the abdominal acupuncture points ST-29 (guilai) were stimulated using simple needle insertion, 2 Hz burst EA or 10 Hz EA, in three different groups. In the second stage of the study, abdominal acupuncture points ST-25 (tianshu) were stimulated with the frequency found to be more effective in stage one. Stimulation was for 5 minutes in each group.
INTERVENTION(S): Electroacupuncture and Doppler flowmeter.
MAIN OUTCOME MEASURE(S): Four groups were compared for volume flow and other related parameters of TBF.
RESULT(S): The 10-Hz EAcupuncture stimulation of ST-29 (guilai) increased TBF, but simple needle insertion and 2-Hz burst stimulation did not. The 10-Hz EA stimulation of ST-25 (tianshu) did not result in significant changes in TBF.
CONCLUSION(S): For the first time point- and frequency-specific effects of abdominal E Acupuncture on testiclar blood flow are shown in humans. Further investigation is required to ascertain whether these findings may be helpful in the clinical treatment of infertile men.
In this study acupuncture effectively helped patients suffering from both reduced sperm motility and low sperm count. This kind of condition is called oligoasthenozoospermia. The study showed that acupuncture significantly improved percentage of motile sperm.
Fertil Steril. 2009 Oct;92(4):1340-3. doi: 10.1016/ j.fertnstert. 2009.02.041. Epub 2009 Apr 25.
A prospective randomized placebo-controlled study of the effect of acupuncture in infertile patients with severe oligoasthenozoospermia.
Dieterle S, Li C, Greb R, Bartzsch F, Hatzmann W, Huang D.
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Witten/Herdecke, Dortmund, Germany. email@example.com
In this first prospective, randomized, single-blind, placebo-controlled study, 28 infertile patients with severe oligoasthenozoospermia received acupuncture according to the principles of traditional Chinese medicine (TCM) and 29 infertile patients received placebo acupuncture. A significantly higher percentage of motile sperm (World Health Organization categories A-C), but no effect on sperm concentration, was found after acupuncture compared with placebo acupuncture.
Acupuncture improves sperm quality. The mechanism of this improvement may lay in decreased temperature of the scrotum.
It’s well known that sperm doesn’t like heat. Inflammation is one of the worst sources of heat you can have. In this study acupuncture normalised scrotal temperature in patients who had inflammation. But it didn’t affect the guys who had a healthy temperature at the start of the study. It shows acupuncture’s regulatory effect – it helps for the body to self regulate, but it doesn’t disrupt healthy balance.
But most importantly, 15 out of 17 men who had improved sperm count.
Success of acupuncture treatment in patients with initially low sperm output is associated with a decrease in scrotal skin temperature.
Siterman S, Eltes F, Schechter L, Maimon Y, Lederman H, Bartoov B.
Poor spermatogenesis in patients with inflammation of the genital tract is associated with scrotal hyperthermia. These patients can benefit from acupuncture treatment. We conducted a study to verify whether the influence of acupuncture treatment on sperm output in patients with low sperm density is associated with a decrease in scrotal temperature.
The experimental group included 39 men who were referred for acupuncture owing to low sperm output. The control group, which comprised 18 normal fertile men, was used to define a threshold (30.5 degrees C) above which scrotal skin temperature was considered to be high. Accordingly, 34 of the 39 participants in the experimental group initially had high scrotal skin temperature; the other five had normal values. Scrotal skin temperature and sperm concentration were measured before and after acupuncture treatment. The five patients with initially normal scrotal temperatures were not affected by the acupuncture treatment.
Following treatment, 17 of the 34 patients with hyperthermia, all of whom had genital tract inflammation, had normal scrotal skin temperature; in 15 of these 17 patients, sperm count was increased. In the remaining 17 men with scrotal hyperthermia, neither scrotal skin temperature nor sperm concentration was affected by the treatment.
About 90% of the latter patients suffered from high gonadotropins or mixed etiological factors. Low sperm count in patients with inflammation of the genital tract seems to be associated with scrotal hyperthermia, and, consequently, acupuncture treatment is recommended for these men.
Effect of acupuncture on sperm parameters of males suffering from subfertility related to low sperm quality.
Siterman S, Eltes F, Wolfson V, Zabludovsky N, Bartoov B.
Institute of Chinese Medicine, Tel Aviv, Israel.
The aim of this prospective controlled study was to assess the effect of acupuncture on the sperm quality of males suffering from subfertility related to sperm impairment. Semen samples of 16 acupuncture-treated subfertile patients were analyzed before and 1 month after treatment (twice a week for 5 weeks). In parallel, semen samples of 16 control untreated subfertile males were examined. Two specimens were taken from the control group at an interval of 2-8 months. The expanded semen analysis included routine and ultramorphological observations. The fertility index increased significantly (p < or = .05) following improvement in total functional sperm fraction, percentage of viability, total motile spermatozoa per ejaculate, and integrity of the axonema (p < or = .05), which occurred upon treatment. The intactness of axonema and sperm motility were highly correlated (corr. = .50, p < or = .05). Thus, patients exhibiting a low fertility potential due to reduced sperm activity may benefit from acupuncture treatment.
The Role of Acupuncture in the Management of Subfertility
Ng E H et al Fertil Steril. 2008 Jul;90(1):1-13.
Fertility and Sterility
OBJECTIVE: To review systematically the use of acupuncture in the management of subfertility.
DESIGN: A computer search was performed via several English and Chinese databases to identify journals relevant to the subject.
RESULT(S): The positive effect of acupuncture in the treatment of subfertility may be related to the central sympathetic inhibition by the endorphin system, the change in uterine blood flow and motility, and stress reduction. Acupuncture may help restore ovulation in patients with polycystic ovary syndrome, although there are not enough randomized studies to validate this.
There is also no sufficient evidence supporting the role of acupuncture in male subfertility, as most of the studies are uncontrolled case reports or case series in which the sample sizes were small. Despite these deficiencies, acupuncture can be considered as an effective alternative for pain relief during oocyte retrieval in patients who cannot tolerate side effects of conscious sedation.
The pregnancy rate of IVF treatment is significantly increased, especially when acupuncture is administered on the day of embryo transfer.
CONCLUSION(S): Although acupuncture has gained increasing popularity in the management of subfertility, its effectiveness has remained controversial.
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Effect of Chinese medicinal herbs on sperm membrane of infertile male
[Article in Chinese]
Shandong Institute of Traditional Chinese Medicine and Materia Medica, Jinan.
The authors carried on the quantitative analysis of fluorescence polarization degree and fluorescent intensity on wheat germ agglutinin (WGA) receptor in sperm membrane surface and protein macromolecule 1-Anilinonaph thalene-8-suphonic acid salt (1,8-ANS) of sperm membrane to the patients with infertility and adult male with normal fertility, with the method of ultraviolet microspectrofluorometer (SMP, type: 05, made in West Germany). The results were as follows: the patient’s WGA receptor in sperm membrane surface was decreased (P less than 0.001), and the 1, 8-ANS of fluorescent intensity in hydrophobic area of protein macromolecule of sperm membrane was increased (P less than 0.05). After the treatment of Shenjing Zhongzitang, WGA receptor was increased obviously and 1, 8-ANS of fluorescent intensity was changed to be almost normal. It showed that the Chinese medicinal herbs mentioned above have certain influence upon the constitution of WGA receptor and protein macromolecule of sperm membrane.
Zhong Xi Yi Jie He Za Zhi. 1990 Sep;10(9):519-21, 515.
https://infertility-acupuncture.info/wp-content/uploads/2015/03/Infertility-acupuncture-logo-300x152.png00Vitalis Skiauterishttps://infertility-acupuncture.info/wp-content/uploads/2015/03/Infertility-acupuncture-logo-300x152.pngVitalis Skiauteris2007-05-20 19:54:342015-02-24 17:45:04Effect of Chinese medicinal herbs on sperm membrane of infertile male
Quantitative evaluation of spermatozoa ultrastructure after acupuncture treatment for idiopathic male infertility.
Pei J, Strehler E, Noss U, Abt M, Piomboni P, Baccetti B, Sterzik K.
Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China. firstname.lastname@example.org
OBJECTIVE: To evaluate the ultramorphologic sperm features of idiopathic infertile men after acupuncture therapy. DESIGN: Prospective controlled study. SETTING: Christian-Lauritzen-Institut, Ulm, IVF center Munich, Germany, and Department of General Biology, University of Siena, Siena, Italy. PATIENT(S): Forty men with idiopathic oligospermia, asthenospermia, or teratozoospermia. INTERVENTION(S): Twenty eight of the patients received acupuncture twice a week over a period of 5 weeks. The samples from the treatment group were randomized with semen samples from the 12 men in the untreated control group. MAIN OUTCOME MEASURE(S): Quantitative analysis by transmission electron microscopy (TEM) was used to evaluate the samples, using the mathematical formula based on submicroscopic characteristics. RESULT(S): Statistical evaluation of the TEM data showed a statistically significant increase after acupuncture in the percentage and number of sperm without ultrastructural defects in the total ejaculates. A statistically significant improvement was detected in acrosome position and shape, nuclear shape, axonemal pattern and shape, and accessory fibers of sperm organelles. However, specific sperm pathologies in the form of apoptosis, immaturity, and necrosis showed no statistically significant changes between the control and treatment groups before and after treatment.
CONCLUSION(S): The treatment of idiopathic male infertility could benefit from employing acupuncture. A general improvement of sperm quality, specifically in the ultrastructural integrity of spermatozoa, was seen after acupuncture, although we did not identify specific sperm pathologies that could be particularly sensitive to this therapy.
Influence of acupuncture on idiopathic male infertility in assisted reproductive technology.
Zhang M, Huang G, Lu F, Paulus WE, Sterzik K.
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030.
The clinical effects of acupuncture on idiopathic male infertility in sperm parameter and on therapeutic results in assisted reproductive technology were investigated. 22 patients failed in intracytoplasmic sperm injection (ICSI) with idiopathic male infertility were treated with acupuncture twice weekly for 8 weeks, followed by ICSI treatment again. The sperm concentration, motility, morphology, fertilization rates and embryo quality were observed. Quick sperm motility after acupuncture (18.3% +/- 9.6%) was significantly improved as compared with that before treatment (11.0% +/- 7.5%, P < 0.01). The normal sperm ratio was increased after acupuncture (21.1% +/- 10.4% vs 16.2% +/- 8.2%, P < 0.05). The fertilization rates after acupuncture (66.2%) were obviously higher than that before treatment (40.2%, P < 0.01). There was no significant difference in sperm concentration and general sperm motility between before and after acupuncture. The embryo quality after acupuncture was improved, but the difference between them was not significant (P > 0.05). Acupuncture can improve sperm quality and fertilization rates in assisted reproductive technology.
J Huazhong Univ Sci Technolog Med Sci. 2002;22(3):228-30.
P.C. Magarelli, D.K. Cridennda. Reproductive Medicine & Fertility Center, Colorado Springs, CO.
Background and Significance: The utility of acupuncture in the treatment of infertility has been demonstrated in two controlled studies. The first study determined the effect of reducing the Pulsatility Index (PI) of the uterine artery on reproductive outcomes; the second study described a Pre/Post embryo transfer protocol that enhanced overall pregnancy rates (PR). There are no studies that have utilized both techniques.
Objective: The purpose of the study was to determine the influence of these two acupuncture protocols on IVF outcomes and secondly to identify the appropriate patient groups that would most benefit from this adjunctive therapy. Read more
Effects of the combined therapy of acupuncture with herbal drugs on male immune infertility–a clinical report of 50 cases.
Fu B, Lun X, Gong Y.
Department of Acupuncture, Second Guangdong Provincial Worker’s Hospital, Guangzhou 510720, China.
To study the clinical effects of the combined therapy of acupuncture with herbal drugs on male immune infertility and on antisperm antibody (AsAb), 100 male cases of infertility with positive AsAb were divided randomly into two groups, each consisting of 50 cases. The acupuncture-drug group was treated with acupuncture on Ganshu (BL 18), Shenshu (BL 23), Taichong (LR 3), Taixi (KI 3), Xinshu (BL 15), Geshu (BL 17), Shenmen (HT 7), and Xuehai (SP 10), combined with oral medication of Liuwei Dihuang Wan (Bolus of the Six Drugs Including Rehmanniae). The control group was treated with oral prednisone. The clinical therapeutic effects and the impact on AsAb were observed in the two groups. The results showed that the total effective rate in the acupuncture-drug group was 90%; while that of the control group was 64%, the comparison showing a statistically significant difference (P<0.05). The positive rate of blood serum and/or AsAb in both the two groups decreased in varying degrees, but the negative-turning rate of AsAb in the acupuncture-drug group was more obvious, the comparison showing also a significant difference (P<0.05). CONCLUSION: The combined therapy of acupuncture with herbal drugs has definite therapeutic effects on male immune infertility, which can regulate AsAb and raise the immunity of the patients.
Controlled trial of acupuncture effects in assisted reproduction therapy
Paulus W.E.1, Zhang M.2, Strehler E.1, Seybold B.1 and Sterzik K.Christian-Lauritzen-Institut, Reproductive Medicine, Ulm, Germany and 2Tongji Medical University, Department of Traditional Chinese Medicine, Wuhan, China
Introduction: In a former published prospective randomized study we demonstrated the benefitt of acupuncture on the pregnancy rate in assisted reproduction therapy by comparing a group of patients receiving acupuncture treatment shortly before and after embryo transfer, with a control group receiving no acupuncture. To rule out the possibility that acupuncture produces only psychological or psychosomatic effects, we used a placebo needle set as a control in the present study.
Materials and Methods:Two hundred patients undergoing ICSI or IVF in our fertility centre were included in this prospective, randomized, placebo controlled trial. Only patients with good embryo quality were admitted. They were divided into two groups by random selection: embryo transfer with verum acupuncture (n = 100) and embryo transfer with placebo needling (n = 100). Verum acupuncture was performed in 100 patients 25 min before and after embryo transfer. In the control group (n = 100) a placebo needle set was used without penetrating the skin, but at the same acupoints and after the same scheme. Before embryo transfer we used the following locations: Cx6 (Neiguan), Sp8 (Diji), Liv3 (Taichong), Gv20 (Baihui) and S29 ( Guilai). After embryo transfer, the sterile disposable stainless steel needles (0.25 3 25 mm) were inserted at the following points: S36 (Zusanli), Sp6 (Sanyinjiao), Sp10 (Xuehai) and Li4 (Hegu). After 10 min the needles were rotated. The main outcome measure was clinical pregnancy defined by the presence of a fetal sac at ultrasound examination 6 weeks after embryo transfer. The Chi-squared test was used for comparison of both groups.
Results: Clinical pregnancies were documented in 43 of 100 patients (43.0%) in the acupuncture group, whereas pregnancy rate reached 37.0% (37 out of 100 patients) in the control group. A significant difference between verum acupuncture and placebo needling could not be demonstrated (P = 0.39).
Conclusion:The missing advantage of verum acupuncture versus placebo needling may be due to the methodical problem that real placebo models for acupuncture are lacking. Our placebo needle set induces an acupressure effect thus leading to a higher pregnancy rate than in our population without any complementary treatment.
https://infertility-acupuncture.info/wp-content/uploads/2015/03/Infertility-acupuncture-logo-300x152.png00Vitalis Skiauterishttps://infertility-acupuncture.info/wp-content/uploads/2015/03/Infertility-acupuncture-logo-300x152.pngVitalis Skiauteris2007-03-11 11:24:382015-02-24 17:45:26Acupuncture and ART
Effects of ferulic acid on fertile and asthenozoospermic infertile human sperm motility, viability, lipid peroxidation, and cyclic nucleotides.
Zheng RL, Zhang H.
Department of Biology, Lanzhou University, P.R. China.
The capacity of human sperm fertilization principally depends on sperm motility and membrane integrity. Reactive oxygen species, such as superoxide anion and hydrogen peroxide, are known to impair sperm motility and membrane integrity by inducing membrane lipid peroxidation (LPO). Ferulic acid (FA), an effective constituent in various medicinal herbs, has recently been shown to scavenge oxygen free radicals and increase the intracellular cAMP and cGMP. The aim of this study is to investigate the effects of FA on human sperm motility, viability, lipid peroxidation, and cyclic nucleotides in fertile and asthenozoospermic infertile individuals in vitro. The sperm samples were obtained from 10 fertile volunteers and 10 asthenozoospermic infertile patients. Washed spermatozoa were incubated at 37 degrees C in Ham’s F-10 medium with 0, 0.1, 0.2, 0.4, 0.8, or 1.6 mM of FA. Samples were analyzed for viability, determined by eosin-Y dye exclusion method at 0, 1, 2, 3, 5, and 6 h of incubation; motility, determined by the trans-membrane migration method within 2 h of incubation; LPO, determined by thiobarbituric acid (TBA) method at 3 h of incubation and the intracellular cAMP and cGMP, determined, respectively, by 3H-cAMP and 125I-cGMP radioimmunoassay at 3 h of incubation. The results showed: in both fertile and infertile spermatozoa, the viability, trans-membrane migration ratio (TMMR) and the levels of intracellular cAMP and cGMP in FA-treated spermatozoa were significantly higher than those of spermatozoa in control groups, while TBA-reactive substances contents in treated spermatozoa were significantly lower than those in control spermatozoa. The effects of FA on these processes were concentration dependent. These data suggested that FA is beneficial to sperm viability and motility in both fertile and infertile individuals, and that reduction of lipid peroxidative damage to sperm membranes and increase of intracellular cAMP and cGMP may be involved in these benefits. It is possible that FA may be used for cure of asthenozoospermic infertility.
https://infertility-acupuncture.info/wp-content/uploads/2015/03/Infertility-acupuncture-logo-300x152.png00Vitalis Skiauterishttps://infertility-acupuncture.info/wp-content/uploads/2015/03/Infertility-acupuncture-logo-300x152.pngVitalis Skiauteris2007-02-20 19:54:352015-02-24 17:45:26Effects of ferulic acid on fertile and asthenozoospermic infertile human sperm motility, viability, lipid peroxidation, and cyclic nucleotides.
Clinical observation on effect of combination of zhuanyindan and hormone in treating male infertility with positive antisperm antibody
[Article in Chinese]
Yu AL, Zhang FZ, Zhang FX.
Taishan Medical College, Shandong 271000.
OBJECTIVE: To explore the therapeutic effect of combination of Zhuanyindan (ZYD, a Chinese herbal preparation) and hormone in treating male infertility with positive antisperm antibody and its influence on nitric oxide (NO) level. METHODS: Eighty-two patients were randomly divided (according to the digital list) into the WM group (n = 20, treated with prednisone), the TCM group (n = 28, treated with ZYD) and the ICWM group (n = 34, treated with prednisone plus ZYD). The clinical effect, negative converting rate of antisperm antibody, changes of NO level in semen and various parameters of sperm motion before and after treatment were observed. RESULTS: The total effective rate in the ICWM group was 88.2%, that in the TCM group 75.0% and in the WM group 65.0%. Significant difference was seen in the ICWM and TCM group before and after treatment in NO level, sperm motion parameters, including linear motion speed, linearity, propulsion, whip frequency, sperm vitality and mean moving angle, and quality of semen (P < 0.05 or P < 0.01). In the WM group, significant difference in comparison before and after treatment was seen in NO level, propulsion, whip frequency, mean moving angle and quality of semen, including vitality and survival rate (P < 0.01).
CONCLUSION: Combination of Chinese herbs and hormone could lower the NO (nitric oxide) level in semen and improve the quality of sperm.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 Mar;24(3):223-6.
https://infertility-acupuncture.info/wp-content/uploads/2015/03/Infertility-acupuncture-logo-300x152.png00Vitalis Skiauterishttps://infertility-acupuncture.info/wp-content/uploads/2015/03/Infertility-acupuncture-logo-300x152.pngVitalis Skiauteris2007-01-19 21:41:392015-02-24 17:45:26Combination of Chinese herbs and hormones could lower the NO (nitric oxide) level in semen and improve the quality of sperm