clomophene pcos acupunctureThis study by Beijing Hospital of Obstetrics and Gynecology has shown acupuncture to be superior to clomophene on ovulation and pregnancy rates in treatment of polycystic ovary syndrome.

Other studies have shown that unlike Clomophene, acupuncture can have long term effect on PCOS by reducing the sympathetic nervous tonus. Apart from study methodology issues, another limitation of this study is that it only looked into the short term effect, but didn’t evaluate the effectiveness over a longer term. However, this is another study adding to the body of evidence. The study was published in the journal of Zhongguo Zhen jiu (Chinese Journal of Acupuncture & Moxibustion [2013, 33(11):961-964]).

Efficacy and safety evaluation of acupuncture combined with auricular acupoint therapy in the treatment of polycystic ovary syndrome

Department of Acupuncture and Physical Therapy, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China. geyongchun1981@sina.com
Zhongguo Zhen jiu = Chinese Acupuncture & Moxibustion [2013, 33(11):961-964]
Type: Journal Article, English Abstract (lang: chi)

OBJECTIVE: To compare the efficacy differences between acupuncture combined with auricular acupoint therapy and clomiphene oral administration in the treatment of polycystic ovary syndrome (PCOS).

METHODS: One hundred cases of PCOS were randomized into two groups, 50 cases in each one. Acupuncture combined with auricular acupuncture group (group A): acupuncture was applied at Guanyuan (CV 4), Zhongji (CV 3) and Zigong (EX-CA 1), once daily; auricular point sticking was applied at Spleen (pi, CO13), Endocrine (neifenmi, CO18), Uterus and Kidney (shen, CO10), the plaster was changed once a week. Clomiphene group (group B): oral clomiphene was prescribed at the 5th day of the menstrual, for 5 consecutive days, totally 3 menstrual cycles was needed. The ovulation induction, pregnancy and menstruation resuming of patients in the two ‘ , The totally effective rate was 90.00% (45/50) in group A, which was group were observed and compared.

RESULTS: The totally effective rate was 90.0% (45/50) in group A, which was superior to 86.0% (43/50) in group B (P<0.05); the ovulation rate and pregnancy rate were 68.0% (34/50)and 64. 0% (32/50) in group A, which were superior to that of group B (all P<0. 05); the menstruation resuming rate was 94.00 (47/50) in group A, which was superior to 88.00 (44/50) in group B (P<0.05). No adverse effect was observed in group A, while in group B, varying degrees of nausea, vomiting, headache and dermatitis were observed in 29 cases, ovarian hyperstimulation syndrome (OHSS) like polycystic ovary was observed in 14 cases under the B ultrasound.CONCLUSION: Acupuncture combined with auricular acupoint therapy has a better effect than clomiphene in the treatment of PCOS without any adverse effects.

pcos-acupuncture-effect A truly thorough, well-referenced paper exploring the mechanism and effects of acupuncture on PCOS. Written by leading PCOS researchers from the Karolinska Institute in Sweden.

Polycystic Ovary Syndrome: Effect and Mechanisms of Acupuncture for Ovulation Induction

Julia Johansson and Elisabet Stener-Victorin

Abstract

Polycystic ovary syndrome (PCOS), the most common endocrine disorder among women of reproductive age, is characterized by the coexistence of hyperandrogenism, ovulatory dysfunction, and polycystic ovaries (PCO). PCOS also represents the largest part of female oligoovulatory infertility, and the management of ovulatory and menstrual dysfunction comprises a third of the high costs of PCOS treatment. Current pharmacological and surgical treatments for reproductive symptoms are effective, however, associated with negative side effects, such as cardiovascular complications and multiple pregnancies. For menstrual irregularities and ovulation induction in women with PCOS, acupuncture has indicated beneficial effects. This review will focus on the results from randomized controlled acupuncture trials for the regulation of menstrual dysfunction and for inducing ovulation in women with PCOS although there are uncontrolled trials with nonetheless interesting results. Animal experimental studies will be further discussed when they can provide a more mechanistic explanatory view.
Read more

Can acupuncture improve embryo quality?

The short answer is yes, acupuncture can improve embryo quality. Now let’s have a look into study details.

Dr Rashidi and his team explored if acupuncture can improve pregnancy rates for PCOS patients undergoing IVF and ICSI. As a result, they found that acupuncture can improve embryo quality.

Read more

acupuncture-pcosAcupuncture showed considerable advantages over the metformin for obese PCOS patients. Acupuncture was shown to be more effective then metformin at improving menstrual freqency, reducing body mass index and waist to hip ratio. It also had fewer side-effects.

Effectiveness of Abdominal Acupuncture for Patients with Obesity-Type Polycystic Ovary Syndrome: A Randomized Controlled Trial
To cite this article:
Yan-Hua Zheng, Xin-Hua Wang, Mao-Hua Lai, Hong Yao, Hua Liu, and Hong-Xia Ma. The Journal of Alternative and Complementary Medicine. -Not available-, ahead of print. doi:10.1089/acm.2012.0429.

Online Ahead of Print: May 15, 2013 Read more

This study demonstrates that acupuncture has a synergystic effect with Chinese Herbal medicine in treatment of Endometriosis. Furthermore the effect of acupuncture and herbal medicine was found to be superior to a pharmaceutical medicine Danazol. The abstract of the study is below.
Acupuncture Chinese medicine Endometriosis

Acupuncture enhances the effects of Chinese herbal Medicine in treatment of Endometriosis

J. Shi, Z. B. Z. Ge*
, Y. Jin,Y. D. Li and J. Zhou** The 1st Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, China
*Sir Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, Zhejiang, China
**College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang, 310012, China. Corresponding Author Email: juezhou2006@yahoo.com.cn

ABSTRACT

The present study was aimed to investigate whether acupuncture could significantly enhance the efficacy of Chinese herbal medicine (CHM) in treating endometriosis model rats. A total of 40 female Sprague-Dawley (SD) rats with body weight of 200 ±20 g were included. Operational transplantation was used with animal models. The rats were randomly divided into 5 groups: sham-operation control group (Group A), model group (Group B), CHM combined with acupuncture group (Group C), CHM group (Group D), Danazol group (Group E) with 8 rats in each group. During the treatment, two rats in Group B and one rat in Group E passed away. When the treatment ended, all the left rats were sacrificed. The samples of peritoneal fluids, serum and the ectopic endometrium were taken. The serum levels of cancer antigen 125 (CA-125) and interleukin 18(IL-18) in the peritoneal fluids were detected using enzyme-linked immune-sorbent assay. The cyclooxygenase-2 (COX-2) mRNA expression levels in the ectopic endometrium were measured by Real-time PCR. The results showed that in the rats from Groups A, C, D and E, the serum CA-125 levels, COX-2 mRNA expression in the ectopic endometrium and the IL-18 levels in the peritoneal fluids were significantly lower than those of Group B (P<0.05). The serum CA-125 levels and COX-2 mRNA expression in the ectopic endometrium of the rats in Group C were significantly lower than those of Group D (P<0.05), while there was no significant difference between Group C and E (P>0.05). The levels of IL-18 in the peritoneal fluids of the rats in Group C were markedly lower than those of Group D and E (P<0.05). It is then concluded that acupuncture treatment can improve the effects of CHM in treating endometriosis model rats. Key words: Chinese herbal medicine acupuncture; endometriosisReference: The Journal of Animal & Plant Sciences, 23(1): 2013, Page: 298-303 ISSN: 1018-7081

You can find a copy of the study here.

Zhonghua Nan Ke Xue. 2012 Dec;18(12):1105-7.
[Compound Xuanju Capsule combined with vitamin E improves sperm chromatin integrity].
[Article in Chinese]
Song B1, He XJ, Jiang HH, Peng YW, Wu H, Cao YX.
Abstract
OBJECTIVE:
To investigate the clinical effects of the combined therapy of the Chinese medicine Compound Xuanju Capsule and vitamin E on sperm chromatin damage in idiopathic oligoasthenospermia.

METHODS:
We assigned 50 infertile men with seminal abnormality to a control group (n = 26) and a trial group (n = 24) to receive vitamin E and the combined therapy of Compound Xuanju Capsule plus vitamin E, respectively, both treated for 3 months. Before and after the treatment, we detected semen routine parameters and sperm DNA fragmentation indexes (DFI) by computer aided semen analysis (CASA) and sperm chromatin structure assay (SCSA), and compared them between the two groups.

RESULTS:
There was no obvious difference between the percentage of progressively motile sperm in the trial group and that in the control group (21.55 +/- 8.68 vs 21.47 +/- 11.53, P > 0.05). The trial group showed a significantly decreased sperm DFI after medication as compared with pre-medication (29.57 +/- 12.19 vs 34.09 +/- 10.32, P < 0.05).

CONCLUSION:
The combined therapy of Compound Xuanju Capsule and vitamin E can effectively improve seminal quality and reduce sperm chromatin damage in infertile men with idiopathic oligoasthenospermia.

PMID: 23405792 [PubMed – indexed for MEDLINE]

This systematic review on Acupuncture and IVF is especially interesting. The studies of the well researched German protocol show acupuncture to be effective on the day of embryo replacement. This systematic review shows that acupuncture during ovarian stimulation also plays significant role in increasing the pregnancy outcomes of IVF.


The role of acupuncture in assisted reproductive technology.
Zheng CH, Zhang MM, Huang GY, Wang W.

Abstract
The aim of this paper was to provide reliable evidence by performing a systematic review and meta-analysis for evaluating the role of acupuncture in assisted reproductive technology. All randomized controlled trials that evaluated the effects of acupuncture, including manual, electrical, and laser acupuncture (LA) techniques, on the clinical pregnancy rate (CPR) and live birth rate (LBR) of in vitro fertilization (IVF) or artificial insemination were included. The controlled groups consisted of no acupuncture and sham acupuncture groups. The sham acupuncture included sham acupuncture at acupoints, sham acupuncture at non- or inappropriate points, sham LA, and adhesive tapes. Twenty-three trials (a total of 5598 participants) were included in this paper. The pooled CPR from all acupuncture groups was significantly higher than that from all controlled groups, whereas the LBR was not significantly different between the two groups. However, the results were quite distinct when the type of control and/or different acupuncture times were examined in a sensitivity analysis. The results mainly indicate that acupuncture, especially around the time of the controlled ovarian hyperstimulation, improves pregnancy outcomes in women undergoing IVF. More positive effects from acupuncture in IVF can be expected if a more individualized acupuncture programs are used.

Full text of the study can be found here.

iui-acupuncture-european-journal
Acupuncture and herbs increased IUI success rate from 39.4% to 65.5% in this study. The difference in the success rates is even more interesting, considering that the control group, who didn’t receive acupuncture was on average 2.3 years younger. The control group was 37.1 years old and the treatment group was 39.4. Normally, you’d expect much lower pregnancy rates in 39 year olds.

Acupuncture and Chinese herbal treatment for women undergoing intrauterine insemination
Keren Sela, Ofer Lehavi, Amnon Buchan, Karin Kedar-Shalema, Haim Yavetz, Shahar Lev-ari

Unit of Complementary Medicine, Tel Aviv Sourasky Medical Center, Affiliated to the Sackler Faculty of Medicine,

Tel Aviv University, 6 Weizmann St., Tel Aviv 64239, Israel

Fertility Research Institute, Tel Aviv Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

Aim: To assess the effect of traditional Chinese medicine (TCM, acupuncture and medicinal herbs) as a therapeutic adjuvant to ovulation induction with intrauterine insemination (IUI) procedures and evaluate its contribution to pregnancy and “take-home baby” rates.

Materials and methods: A comparative retrospective study was carried out in a university – affiliated municipal hospital. All women undergoing artificial insemination by donor spermatozoa (AID) and concomitantly treated with TCM were invited to participate. The enrolled women underwent weekly TCM in parallel with medical therapy. The treatment lasted between 2 and 36 cycles (equivalent to a time period ranging from one month to one year). The control group was comprised of women who underwent AID without TCM and whose data were retrospectively retrieved from hospital files. Pregnancy was assessed by human chorionic gonadotropin findings in blood 12–14 days after IUI. The birth rate was calculated during follow-up.

Results: A total of 29 women aged 30–45 years were enrolled in the study. The historical control group included 94 women aged 28–46 years.

Results over an average 4-5 months cumulative period:
1. Acupuncture and herbs plus IUI; average age 39.43 years
2. Control group – IUI (DI) only; average age 37.12 years

Women who combined TCM with the procedures for undergoing IUI had significantly higher pregnancy (OR = 4.403, 95% CI 1.51–12.835,
p = 0.007) and birth rates (OR = 3.905, 95% CI 1.321–11.549, p = 0.014) than the control group.

Conclusions: TCM appears to be beneficial as an adjunctive treatment in IUI procedures. Randomized controlled trials are needed to further assess the role of acupuncture and herbs in this setting.

Full text of the study here: Acupuncture and Chinese herbal treatment for IUI

What is semen liquefaction? Immediately after ejaculation semen coagulates and then liquefies again within 15 to 20 minutes.  Unfortunately, for about 11.8 per cent of men, diagnosed with infertility, semen does not liquefy.

One of the main causes, why sperm doesn’t liquefy, is inflammation. To be precise, the inflammation of the prostate and seminal vesicles. As a result, because of the impaired function, these glands may secrete less of the sperm fluid. Therefore, lead to lower semen quality and trouble with liquefaction.

This study shows that Chinese herbs can reduce semen liquefaction time. As a result, sperm motility and concentration improved as well.

Shengjing Tablets used in this study include nine TCM/herbal ingredients. The key to success here is not prescribing just any herbs. The most important is the combination and dose of each ingredient that makes the formula successful.

Shengjing tablets for semen non-liquefaction: a clinical study of 100 cases.

[Article in Chinese]
Yang XF, Guo LH, An LH, Pan ZH, Sun L, Ma K

Abstract

OBJECTIVE:
To investigate the efficacy and action mechanism of Shengjing Tablets in the treatment liquefaction.
METHODS:
We randomly assigned 150 patients with semen non-liquefaction to receive Shengjing Tablets group, n = 100) and vitamin E capsules (control group, n = 50) for 2 courses of 45 days each, followed by observation liquefaction time and other semen parameters.
RESULTS:
After the first course, 68 of the patients in the treatment group 20 responded and 12 failed to respond; and after the second course, 84 were cured, 9 responded and 7 failed to respond, the effective rate of 93.0%. In comparison, only 8 of the controls were cured, 8 responded and 34 failed to respond after medication. There were statistically significant differences between the two groups (P < 0.01). Meanwhile, the treatment showed obvious improvement in sperm motility and concentration.

CONCLUSION:
Shengjing Tablets may shorten the time liquefaction and can be used as a safe and effective therapy for semen non-liquefaction.

A comprehensive article explaining how acupuncture may help prevent miscarriages.

BMC Complement Altern Med. 2012 Mar 22;12(1):20. [Epub ahead of print]
Acupuncture as a therapeutic treatment option for threatened miscarriage.
Betts D, Smith CA, Hannah DG.
Abstract
ABSTRACT:
BACKGROUND:
Threatened miscarriage involves vaginal bleeding in a pregnancy that remains viable. This is a common early pregnancy complication with increased risk factors for early pregnancy loss, preterm premature rupture of membranes (PPROM), preterm delivery, low birth weight babies and maternal antepartum haemorrhage. Currently there are no recommended medical treatment options, rather women receive advice that centres on a ‘wait and see’ approach. For women with a history of unexplained recurrent miscarriage providing supportive care in a subsequent pregnancy improves live birthing outcomes, but the provision of supportive care to women experiencing threatened miscarriage has to date not been examined.
DISCUSSION:
While it is known that 50-70 % of miscarriages occur due to chromosomal abnormalities, the potential for therapeutic intervention amongst the remaining percentage of women remains unknown. Complementary and alternative medicine (CAM) therapies have the potential to provide supportive care for women presenting with threatened miscarriage. Within fertility research, acupuncture demonstrates beneficial hormonal responses with decreased miscarriage rates, raising the possibility acupuncture may promote specific beneficial effects in early pregnancy. With the lack of current medical options for women presenting with threatened miscarriage it is timely to examine the possible treatment benefits of providing CAM therapies such as acupuncture.
SUMMARY:
Despite vaginal bleeding being a common complication of early pregnancy there is often reluctance from practitioners to discuss with women and medical personal how and why CAM may be beneficial. In this debate article, the physiological processes of early pregnancy together with the concept of providing supportive care and acupuncture are examined. The aim is to raise awareness and promote discussion as to the beneficial role CAM may have for women presenting with threatened miscarriage

sperm-fertility-acupuncture-spermatogenesis
This study published in journal of Spermatogenesis contributes to understanding of how acupuncture improves sperm parameters. The researchers found that acupuncture improved Sertoli cell functions. This has enhanced germ cell proliferation. The result is improved motile sperm count. The study design could not evaluate other sperm parameters.

Spermatogenesis. 2012 Jan 1;2(1):53-62.
Electroacupuncture enhances spermatogenesis in rats after scrotal heat treatment.
Gao J, Zuo Y, So KH, Yeung WS, Ng EH, Lee KF.
Abstract
Spermatogenesis is regulated by a cascade of steroid regulated genes in the testis. Recent studies suggested that acupuncture may improve fertility in men with abnormal semen parameters. Yet, the underlying mechanisms in which acupuncture enhances spermatogenesis remain largely unknown. Here we used a scrotal heat-treated rat model to study the effect of electroacupuncture (EA) on recovery of spermatogenesis. In this model, spermatogenesis was disrupted by 30 min scrotal heat treatment at 43°C. Ten sessions of EA were given at Baihui (GV20), Guanyuan (CV4), Zusanli (ST36) and Sanyinjiao (SP6) from day 9 to day 36 post-treatment. Sperm motility and production, morphology of the germinal epithelium by Johnsen’s scoring, germ cell apoptosis by TUNEL staining, proliferation by proliferating cell nuclear antigen (PCNA) staining, as well as serum testosterone and inhibin B levels by immunoassays were evaluated on day 0, 1, 9, 25, 37, 46, 56 and 79. When compared with the heat-treated (H) group, the heat-treated plus EA (H(+)EA) group showed a significant increase (p < 0.05) in PCNA-positive cells and inhibin B levels on days 37 and 46, and a higher Johnsen's score till day 56. On day 79, motile spermatozoa could be found in the vas deferens of H(+)EA group only. Consistently, there was a trend of improved motility and increased number of motile epididymal spermatozoa in the H(+)EA group than the H group; while apoptosis of germ cells and serum testosterone levels were similar between the two groups. Taken together, EA enhanced germ cell proliferation through improvement of Sertoli cell functions. This may facilitate the recovery of spermatogenesis and may restore normal semen parameters in subfertile patients.

Electrical and manual acupuncture stimulation affects estrous cyclicity and neuroendocrine function in a DHT-induced rat polycystic ovary syndrome model

Yi Feng, Julia Johansson, Ruijin Shao, Louise Mannerås Holm, Håkan Billig, Elisabet Stener-Victorin

Abstract

Both low-frequency electro-acupuncture (EA) and manual acupuncture improve menstrual frequency and decrease circulating androgens in women with polycystic ovary syndrome (PCOS). We sought to determine whether low-frequency EA is more effective than manual stimulation in regulating disturbed estrous cyclicity in rats with PCOS induced by 5?-dihydrotestosterone (DHT). To identify the central mechanisms of the effects of stimulation, we assessed hypothalamic mRNA expression of molecules that regulate reproductive and neuroendocrine function.

From age 70 days, rats received 2-Hz EA or manual stimulation of the needles five times/week for 4–5 weeks; untreated rats served as controls. Specific hypothalamic nuclei were obtained by laser microdissection, and mRNA expression was measured with TaqMan low-density arrays. Untreated rats were acyclic. During the last 2 weeks of treatment, seven of eight (88%) rats in the EA group had epithelial keratinocytes, demonstrating estrous cycle change (p= 0.034 vs. controls). In the manual group, five of eight (62%) rats had estrous cycle changes (ns vs. controls). mRNA expression of the opioid receptors Oprk1 and Oprm1 in the hypothalamic arcuate nucleus was lower in the EA group than in untreated controls. mRNA expression of the steroid hormone receptors Esr2, Pgr, and Kiss1r was lower in the manual group than in the controls.

In rats with DHT-induced PCOS, low-frequency EA restored disturbed estrous cyclicity but did not differ from manual stimulation group, although electrical stimulation lowered serum testosterone in responders, those with restored estrus cyclicity, and differed from both controls and the manual stimulation group. Thus, EA cannot in all aspects be considered superior to manual stimulation.

The effects of low-frequency EA may be mediated by central opioid receptors, while manual stimulation may involve regulation of steroid hormone/peptide receptors.

Effects of acupuncture on pregnancy rates in women undergoing in vitro fertilization: a systematic review and meta-analysis.

Zheng CH, Huang GY, Zhang MM, Wang W.

Abstract

You can read the full paper here.

OBJECTIVE:
To evaluate the effect of acupuncture on in vitro fertilization (IVF) outcomes.

DESIGN:
Systematic review and meta-analysis.

PATIENT(S):
Women undergoing IVF in randomized controlled trials (RCTs) who were evaluated for the effects of acupuncture on IVF outcomes.

INTERVENTION(S):
The intervention groups used manual, electrical, and laser acupuncture techniques. The control groups consisted of no, sham, and placebo acupuncture.

MAIN OUTCOME MEASURE(S):
The major outcomes were clinical pregnancy rate (CPR) and live birth rate (LBR). Heterogeneity of the therapeutic effect was evaluated with a forest plot analysis. Publication bias was assessed by a funnel plot analysis.

RESULT(S):
Twenty-four trials (a total of 5,807 participants) were included in this review. There were no significant publication biases for most of the comparisons among these studies. The pooled CPR (23 studies) from all of the acupuncture groups was significantly greater than that from all of the control groups, whereas the LBR (6 studies) was not significantly different between the two groups. The results were different when the type of control was examined in a sensitivity analysis. The CPR and LBR differences between the acupuncture and control groups were more obvious when the studies using the Streitberger control were ignored. Similarly, if the underlying effects of the Streitberger control were excluded, the LBR results tended to be significant when the acupuncture was performed around the time of oocyte aspiration or controlled ovarian hyperstimulation.

CONCLUSION(S):
Acupuncture improves CPR and LBR among women undergoing IVF based on the results of studies that do not include the Streitberger control. The Streitberger control may not be an inactive control. More positive effects of using acupuncture in IVF can be expected if an appropriate control and more reasonable acupuncture programs are used.

The Effect of Acupuncture on Psychosocial Outcomes for Women Experiencing Infertility: A Pilot Randomized Controlled Trial

Caroline A. Smith, PhD, Jane M. Ussher, PhD, Janette Perz, PhD, Bridget Carmady, and Sheryl de Lacey, PhD

Abstract

Objectives:

The study objectives were to examine the effectiveness of acupuncture for reducing infertility-related stress.

Design:

The study design was a randomized controlled trial of acupuncture compared with a wait-list control.

Setting:

The study was conducted at The University of Western Sydney.

Subjects:

Thirty-two (32) women aged 20–45 years, with a diagnosis of infertility, or a history of unsuccessfully trying to conceive for 12 months or more, were the subjects of the study.

Interventions:

Women received six sessions of acupuncture for over 8 weeks.

Outcome measures:

The primary outcomes were infertility self-efficacy, anxiety, and infertility-related stress. The women’s experience of infertility and acupuncture is also reported.

Results:

At the end of the 8-week intervention, women in the acupuncture group reported significant changes on two domains on the Fertility Problem Inventory with less social concern (mean difference [MD] ?3.75, 95% confidence interval [CI] ?7.58 to 0.84, p=0.05), and less relationship concern (MD ?3.66, 95% CI ?6.80 to ?0.052, p=0.02). There were also trends toward a reduction of infertility stress on other domains, and a trend toward improved self-efficacy (MD 11.9, 95% CI ? 2.20 to 26.0, p=0.09) and less anxiety (MD ? 2.54, 95% CI ? 5.95 to 0.86, p=0.08) in the acupuncture group compared with the wait-list control. Women described the experience and impact of acupuncture as positive relating to a sense of relaxation and time out, the engagement with the practitioner, and intervention that had very few negative side-effects. Changes were also perceived after treatment with women describing a physical and psychologic sense of relaxation and calmness, and a changed perspective in relation to coping.

Conclusions:

Acupuncture may be a useful intervention to assist with the reduction of infertility-related stress. Further research is justified.

Increase of success rate for women undergoing embryo transfer by transcutaneous electrical acupoint stimulation: a prospective randomized placebo-controlled study

Objective

To evaluate the effect of transcutaneous electrical acupoint stimulation (TEAS) on pregnancy rates (PR) in women undergoing ET.
Design

Prospective, randomized, single-blinded placebo-controlled clinical trial.
Setting

Research and laboratory facilities.
Patient(s)

A total of 309 patients, less than 45 years old, undergoing cryopreservation embryos transplant or fresh cycle IVF with or without intracytoplasmic sperm injection (ICSI).
Intervention(s)

The subjects were randomly allocated to three groups: mock TEAS treatment: 30 minutes after ET (group I, n = 99); single TEAS treatment: 30 minutes after ET (group II, n = 110); and double TEAS treatments: 24 hours before ET and 30 minutes after ET (group III, n = 100).
Main Outcome Measure(s)

Clinical PR, embryos implantation rate, live birth rate.
Result(s)

The clinical PR, embryos implantation rate, and live birth rate of group I (29.3%, 15.0%, and 21.2%, respectively) were significantly lower than those in group II (42.7%, 25.7%, and 37.3%, respectively) and group III (50.0%, 25.9%, and 42.0%, respectively).
Conclusion(s)

Transcutaneous electrical acupoint stimulation, especially double TEAS, significantly improved the clinical outcome of ET.

Key Words: Acupuncture, transcutaneous electrical acupoint stimulation (TEAS), pregnancy rate (PR), in vitro fertilization (IVF), embryo transfer (ET), intracytoplasmic sperm injection (ICSI)


Abstract
Objective
To observe the clinical efficacy of acupuncture-moxibustion therapy for infertility due to sperm abnormality (SAI).
Methods
We treated a series of 35 cases of SAI with electroacupuncture combined with herb cake-partitioned moxibustion, observing the variation before and after treatment in symptom integral, sperm status, sex hormone and prostate function.
Results
After treatment, the patients were remarkably improved in symptom integral, sperm status, sex hormone and prostate function as compared with those prior to treatment.
Conclusion
Acupuncture is an effective therapy for SAI.

Key Words Acupuncture-moxibustion Therapy – Infertility, Male – Spermatozoa – Azoospermia – Oligospermia

Author: He Jinsen, doctor of medicine, professor

human-reproduction-infertility-acupuncture

Title: Effect of electro-acupuncture on ovarian expression of ? (1)- and ? (2)-adrenoceptors, and p75 neurotrophin receptors in rats with steroid-induced polycystic ovaries
Author: Manni Luigi ; Lundeberg Thomas ; Holmäng Agneta ; Aloe Luigi ; Stener-Victorin Elisabet
Abstract:

Abstract

Background

Estradiol valerate (EV)-induced polycystic ovaries (PCO) in rats is associated with an increase in ovarian sympathetic outflow. Low-frequency (2 Hz) electro-acupuncture (EA) has been shown to modulate sympathetic markers as well as ovarian blood flow as a reflex response via the ovarian sympathetic nerves, in rats with EV-induced PCO.

Methods

In the present study, we further tested the hypothesis that repeated 2 Hz EA treatments modulate ovarian sympathetic outflow in rats with PCO, induced by a single i.m. injection of EV, by investigating the mRNA expression, the amount and distribution of proteins of ?1a-, ?1b-, ?1d-, and ?2-adrenoceptors (ARs), as well as the low-affinity neurotrophin receptor (p75NTR).

Results

It was found that EV injection results in significantly higher mRNA expression of ovarian ?1b- and ?1d-AR in PCO rats compared to control rats. The p75NTR and ?2-ARs mRNA expression were unchanged in the PCO ovary. Low-frequency EA resulted in a significantly lower expression of ?2-ARs mRNA expression in PCO rats. The p75NTR mRNA was unaffected in both PCO and control rats. PCO ovaries displayed significantly higher amount of protein of ?1a-, ?1b- and ?1d-ARs, and of p75NTR, compared to control rats, that were all counteracted by repeated low-frequency EA treatments, except for ?1b-AR.

Conclusion

The present study shows that EA normalizes most of the EV-induced changes in ovarian ARs. Furthermore, EA was able to prevent the EV-induced up regulation of p75NTR, probably by normalizing the sympathetic ovarian response to NGF action. Our data indicate a possible role of EA in the regulation of ovarian responsiveness to sympathetic inputs and depict a possible complementary therapeutic approach to overcoming sympathetic-related anovulation in women with PCOS.
Journal: Reproductive Biology and Endocrinology
Issn: 14777827

Title: Effect of electro-acupuncture stimulation of different frequencies and intensities on ovarian blood flow in anaesthetized rats with steroid-induced polycystic ovaries
Author: Stener-Victorin Elisabet ; Kobayashi Rie ; Watanabe Orie ; Lundeberg Thomas ; Kurosawa Mieko
Abstract:

Abstract

Background

Maintenance of ovarian blood flow (OBF) is suggested to be important for regular ovulation in women with polycystic ovaries (PCO). Read more

Gynecological Endocrinology: Acupuncture PCOS
Current evidence of acupuncture on polycystic ovarian syndrome.

Lim CE, Wong WS.

Faculty of Medicine, South Western Sydney Clinical School, University of New South Wales, Sydney, Australia. celim@unswalumni.com Gynecol Endocrinol. 2010 Jun;26(6):473-8.
Abstract

OBJECTIVE: This paper aims to provide a literature review on evaluating the efficacy of acupuncture therapy in the treatment of polycystic ovarian syndrome (PCOS) by reviewing clinical trials; randomised and non-randomised and observational studies on PCOS. The paper will also determine the possible mechanism of acupuncture treatment in PCOS, limitations of recruited studies and suggest further improvements in future studies.
Read more

Acupuncture PCOS Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo/amenorrhea in women with polycystic ovary syndrome: a randomized controlled trial
Elizabeth Jedel1, Fernand Labrie2, Anders Odén3, Göran Holm4, Lars Nilsson5, Per Olof Janson5, Anna-Karin Lind5, Claes Ohlsson6, and Elisabet Stener-Victorin7,8
Read more